Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX8XND
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| Drug Name |
4-Dimethylamino-but-2-enoic acid [4-(1-benzyl-1H-indazol-5-ylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide
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| Synonyms |
CHEMBL180227
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C31H29N7O2
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| Canonical SMILES |
COc1cc2ncc(C#N)c(Nc3ccc4c(cnn4Cc5ccccc5)c3)c2cc1NC(=O)\\C=C\\CN(C)C
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| InChI |
InChI=1S/C31H29N7O2/c1-37(2)13-7-10-30(39)36-27-15-25-26(16-29(27)40-3)33-18-23(17-32)31(25)35-24-11-12-28-22(14-24)19-34-38(28)20-21-8-5-4-6-9-21/h4-12,14-16,18-19H,13,20H2,1-3H3,(H,33,35)(H,36,39)/b10-7+
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| InChIKey |
WOAVUZPOSJDYLY-JXMROGBWSA-N
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| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
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