Drug General Information
Drug ID
DX9ZFG
Drug Name
4-[1-(4-Fluorophenyl)-1H-indazol-5-yl]-N-propyl-3-(trifluoromethyl)benzenesulfonamide
Synonyms
CHEMBL1085380
Indication Discovery agent Investigative [1587926]
Formula
C23H19F4N3O2S
Canonical SMILES
CCCNS(=O)(=O)c1ccc(c2ccc3c(cnn3c4ccc(F)cc4)c2)c(c1)C(F)(F)F
InChI
InChI=1S/C23H19F4N3O2S/c1-2-11-29-33(31,32)19-8-9-20(21(13-19)23(25,26)27)15-3-10-22-16(12-15)14-28-30(22)18-6-4-17(24)5-7-18/h3-10,12-14,29H,2,11H2,1H3
InChIKey
RASBRABSHNFWAA-UHFFFAOYSA-N
Target and Pathway
Target(s) Progesterone receptor Target Info [1587926]
mRNA of androgen receptor Target Info [1587926]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturationhsa04114:Oocyte meiosis
Pathways in cancer
Prostate cancer
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Cellular roles of Anthrax toxinsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY network
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathway
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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