Drug Information
Drug General Information | |||||
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Drug ID |
DXA4TJ
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Drug Name |
2-{4-[7-(1H-Indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-benzylamino}-ethanol
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Synonyms |
CHEMBL310740
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Indication | Discovery agent | Investigative | [1] | ||
Formula |
C24H22N4OS
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Canonical SMILES |
OCCNCc1ccc(cc1)c2cc3nccc(Nc4ccc5[nH]ccc5c4)c3s2
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InChI |
InChI=1S/C24H22N4OS/c29-12-11-25-15-16-1-3-17(4-2-16)23-14-22-24(30-23)21(8-10-27-22)28-19-5-6-20-18(13-19)7-9-26-20/h1-10,13-14,25-26,29H,11-12,15H2,(H,27,28)
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InChIKey |
IUNORHVEZRZFIC-UHFFFAOYSA-N
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Target and Pathway | |||||
Target(s) | Epidermal growth factor receptor III | Target Info | [1] | ||
Vascular endothelial growth factor receptor 1 | Target Info | [1] | |||
KEGG Pathway | Ras signaling pathway | ||||
Rap1 signaling pathway | |||||
Cytokine-cytokine receptor interaction | |||||
HIF-1 signaling pathway | |||||
Endocytosis | |||||
PI3K-Akt signaling pathway | |||||
Focal adhesion | |||||
Transcriptional misregulation in cancer | |||||
Rheumatoid arthritis | |||||
Pathway Interaction Database | Glypican 1 network | ||||
HIF-2-alpha transcription factor network | |||||
S1P3 pathway | |||||
VEGF and VEGFR signaling network | |||||
VEGFR1 specific signals | |||||
Signaling events mediated by VEGFR1 and VEGFR2 | |||||
Reactome | Neurophilin interactions with VEGF and VEGFR | ||||
VEGF binds to VEGFR leading to receptor dimerization | |||||
WikiPathways | Focal Adhesion | ||||
Signaling by VEGF | |||||
Angiogenesis | |||||
References | |||||
REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 | ||||
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