Drug General Information
Drug ID
DXC3BC
Drug Name
1-(4-(3-aminobenzo[d]isoxazol-4-yl)phenyl)urea
Synonyms
CHEMBL270070
Indication Discovery agent Investigative [1587926]
Formula
C14H12N4O2
Canonical SMILES
NC(=O)Nc1ccc(cc1)c2cccc3onc(N)c23
InChI
InChI=1S/C14H12N4O2/c15-13-12-10(2-1-3-11(12)20-18-13)8-4-6-9(7-5-8)17-14(16)19/h1-7H,(H2,15,18)(H3,16,17,19)
InChIKey
QKEZZTSUDGCSDM-UHFFFAOYSA-N
Target and Pathway
Target(s) FL cytokine receptor Target Info [1587926]
Mast/stem cell growth factor receptor Target Info [1587926]
KEGG Pathway Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Central carbon metabolism in cancerhsa04014:Ras signaling pathway
Rap1 signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Melanogenesis
Central carbon metabolism in cancer
NetPath Pathway IL3 Signaling Pathway
IL4 Signaling Pathway
KitReceptor Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
Signaling events mediated by Stem cell factor receptor (c-Kit)
Reactome PIP3 activates AKT signaling
Regulation of KIT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
WikiPathways Kit receptor signaling pathway
Differentiation Pathway
Signaling by SCF-KIT
PIP3 activates AKT signaling
Cardiac Progenitor Differentiation
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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