Drug Information

Drug General Information
Drug ID
DXCZ7M
Drug Name
N-[1-Hydroxycarbamoyl-2-(4-phenoxy-benzenesulfonyl)-1-phenyl-ethyl]-benzamide
Synonyms
CHEMBL419315
Indication Discovery agent Investigative [1587926]
Formula
C28H24N2O6S
Canonical SMILES
ONC(=O)C(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NC(=O)c3ccccc3)c4ccccc4
InChI
InChI=1S/C28H24N2O6S/c31-26(21-10-4-1-5-11-21)29-28(27(32)30-33,22-12-6-2-7-13-22)20-37(34,35)25-18-16-24(17-19-25)36-23-14-8-3-9-15-23/h1-19,33H,20H2,(H,29,31)(H,30,32)
InChIKey
AWEAPFWTHDDCFJ-UHFFFAOYSA-N
Target and Pathway
Target(s) 72 kDa type IV collagenase Target Info [1587926]
Collagenase 3 Target Info [1587926]
KEGG Pathway Leukocyte transendothelial migration
GnRH signaling pathway
Estrogen signaling pathway
Pathways in cancer
Proteoglycans in cancer
Bladder cancer
NetPath Pathway Leptin Signaling Pathway
TCR Signaling Pathway
ID Signaling PathwayNetPath_13:IL1 Signaling Pathway
PANTHER Pathway Alzheimer disease-presenilin pathwayP00004:Alzheimer disease-presenilin pathway
Plasminogen activating cascade
Pathway Interaction Database LPA receptor mediated events
Plasma membrane estrogen receptor signaling
Osteopontin-mediated events
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Angiopoietin receptor Tie2-mediated signaling
Direct p53 effectors
amb2 Integrin signaling
ATF-2 transcription factor network
FOXM1 transcription factor network
Regulation of nuclear beta catenin signaling and target gene transcription
Syndecan-2-mediated signaling eventsupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
EPH-ephrin mediated repulsion of cellsR-HSA-1442490:Collagen degradation
Assembly of collagen fibrils and other multimeric structures
WikiPathways Activation of Matrix Metalloproteinases
AGE/RAGE pathway
Matrix MetalloproteinasesWP474:Endochondral Ossification
Oncostatin M Signaling Pathway
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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