Drug General Information
Drug ID
DXFG7R
Drug Name
N3-(4-(3-morpholinopropoxy)phenyl)-1-(pyridin-2-yl)-1H-1,2,4-triazole-3,5-diamine
Synonyms
CHEMBL1835751
Indication Discovery agent Investigative [1587926]
Formula
C20H25N7O2
Canonical SMILES
Nc1nc(Nc2ccc(OCCCN3CCOCC3)cc2)nn1c4ccccn4
InChI
InChI=1S/C20H25N7O2/c21-19-24-20(25-27(19)18-4-1-2-9-22-18)23-16-5-7-17(8-6-16)29-13-3-10-26-11-14-28-15-12-26/h1-2,4-9H,3,10-15H2,(H3,21,23,24,25)
InChIKey
NIPJQRGYPGKSQY-UHFFFAOYSA-N
Target and Pathway
Target(s) FL cytokine receptor Target Info [1587926]
Mast/stem cell growth factor receptor Target Info [1587926]
KEGG Pathway Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Central carbon metabolism in cancerhsa04014:Ras signaling pathway
Rap1 signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Melanogenesis
Central carbon metabolism in cancer
NetPath Pathway IL3 Signaling Pathway
IL4 Signaling Pathway
KitReceptor Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
Signaling events mediated by Stem cell factor receptor (c-Kit)
Reactome PIP3 activates AKT signaling
Regulation of KIT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
WikiPathways Kit receptor signaling pathway
Differentiation Pathway
Signaling by SCF-KIT
PIP3 activates AKT signaling
Cardiac Progenitor Differentiation
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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