Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXI0NH
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| Drug Name |
(E)-ethyl 4-(3-(6-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)pyrimidin-4-yloxy)phenylamino)-4-oxobut-2-enoate
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| Synonyms |
CHEMBL1928948
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C29H24ClFN4O5
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| Canonical SMILES |
CCOC(=O)\\C=C\\C(=O)Nc1cccc(Oc2cc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)ncn2)c1
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| InChI |
InChI=1S/C29H24ClFN4O5/c1-2-38-29(37)12-11-27(36)35-21-7-4-8-23(14-21)40-28-16-26(32-18-33-28)34-22-9-10-25(24(30)15-22)39-17-19-5-3-6-20(31)13-19/h3-16,18H,2,17H2,1H3,(H,35,36)(H,32,33,34)/b12-11+
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| InChIKey |
XSVCKBHBQOJBFL-VAWYXSNFSA-N
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| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
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