Drug General Information
Drug ID
DXK7QO
Drug Name
6-Cyclohexylamino-9-cyclopentyl-9H-purine-2-carbonitrile
Synonyms
CHEMBL370318
Indication Discovery agent Investigative [1587926]
Formula
C17H22N6
Canonical SMILES
N#Cc1nc(NC2CCCCC2)c3ncn(C4CCCC4)c3n1
InChI
InChI=1S/C17H22N6/c18-10-14-21-16(20-12-6-2-1-3-7-12)15-17(22-14)23(11-19-15)13-8-4-5-9-13/h11-13H,1-9H2,(H,20,21,22)
InChIKey
VNUJPTVFFFXCLL-UHFFFAOYSA-N
Target and Pathway
Target(s) Cathepsin K Target Info [1587926]
Cathepsin L Target Info [1587926]
KEGG Pathway Lysosome
Osteoclast differentiation
Toll-like receptor signaling pathway
Rheumatoid arthritishsa04142:Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritis
NetPath Pathway TGF_beta_Receptor Signaling Pathway
RANKL Signaling Pathway
IL2 Signaling PathwayNetPath_16:IL4 Signaling Pathway
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Trafficking and processing of endosomal TLR
MHC class II antigen presentationR-HSA-1236977:Endosomal/Vacuolar pathway
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
WikiPathways RANKL/RANK Signaling Pathway
Osteoclast SignalingWP2572:Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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