Drug General Information
Drug ID
DXK91K
Drug Name
5-Allyl-2,2,4-trimethyl-10-methylsulfanyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Synonyms
CHEMBL8394
Indication Discovery agent Investigative [1587926]
Formula
C23H25NOS
Canonical SMILES
CSc1cccc2OC(CC=C)c3c(ccc4NC(C)(C)C=C(C)c34)c12
InChI
InChI=1S/C23H25NOS/c1-6-8-17-22-15(21-18(25-17)9-7-10-19(21)26-5)11-12-16-20(22)14(2)13-23(3,4)24-16/h6-7,9-13,17,24H,1,8H2,2-5H3
InChIKey
XTULGNRZXMHXPU-UHFFFAOYSA-N
Target and Pathway
Target(s) Progesterone receptor Target Info [1587926]
mRNA of androgen receptor Target Info [1587926]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturationhsa04114:Oocyte meiosis
Pathways in cancer
Prostate cancer
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Cellular roles of Anthrax toxinsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY network
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathway
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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