Drug General Information
Drug ID
DXL3IC
Drug Name
2-(4-chloro-6-(3-chlorophenylamino)pyrimidin-2-ylthio)-2-(naphthalen-1-yl)acetic acid
Synonyms
CHEMBL1089467
Indication Discovery agent Investigative [1587926]
Formula
C22H15Cl2N3O2S
Canonical SMILES
OC(=O)C(Sc1nc(Cl)cc(Nc2cccc(Cl)c2)n1)c3cccc4ccccc34
InChI
InChI=1S/C22H15Cl2N3O2S/c23-14-7-4-8-15(11-14)25-19-12-18(24)26-22(27-19)30-20(21(28)29)17-10-3-6-13-5-1-2-9-16(13)17/h1-12,20H,(H,28,29)(H,25,26,27)
InChIKey
HVMQERGLUKDWRN-UHFFFAOYSA-N
Target and Pathway
Target(s) Peroxisome proliferator activated receptor gamma Target Info [1587926]
Arachidonate 5-lipoxygenase Target Info [1587926]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway PPAR signaling pathway
AMPK signaling pathway
Osteoclast differentiation
Huntington's disease
Pathways in cancer
Transcriptional misregulation in cancer
Thyroid cancerhsa00590:Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling PathwayNetPath_16:IL4 Signaling Pathway
PANTHER Pathway CCKR signaling map ST
Pathway Interaction Database Noncanonical Wnt signaling pathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Signaling events mediated by HDAC Class I
RXR and RAR heterodimerization with other nuclear receptor
Regulation of retinoblastoma protein
PathWhiz Pathway Arachidonic Acid Metabolism
Reactome PPARA activates gene expression
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
WikiPathways Wnt Signaling Pathway Netpath
Nuclear Receptors in Lipid Metabolism and Toxicity
Differentiation of white and brown adipocyte
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional Regulation of White Adipocyte Differentiation
Adipogenesis
SREBP signalling
Nuclear ReceptorsWP2877:Vitamin D Receptor Pathway
Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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