Drug Information

Drug General Information
Drug ID
DXL83R
Drug Name
1-Methoxy-3-methyl-10-(4-methyl-piperazin-1-yl)-5-phenethyl-5,6,7,12-tetrahydro-2,5,12-triaza-dibenzo[a,e]azulene
Synonyms
CHEMBL551570
Indication Discovery agent Investigative [1587926]
Formula
C30H35N5O
Canonical SMILES
COc1nc(C)cc2N(CCc3ccccc3)CCc4c([nH]c5cc(ccc45)N6CCN(C)CC6)c12
InChI
InChI=1S/C30H35N5O/c1-21-19-27-28(30(31-21)36-3)29-25(12-14-35(27)13-11-22-7-5-4-6-8-22)24-10-9-23(20-26(24)32-29)34-17-15-33(2)16-18-34/h4-10,19-20,32H,11-18H2,1-3H3
InChIKey
AAWMAJBBHSVQCG-UHFFFAOYSA-N
Target and Pathway
Target(s) Hepatocyte growth factor receptor Target Info [1587926]
Insulin-like growth factor I receptor Target Info [1587926]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
Axon guidance
Focal adhesion
Adherens junction
Bacterial invasion of epithelial cells
Epithelial cell signaling in Helicobacter pylori infection
Malaria
Pathways in cancer
Transcriptional misregulation in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Melanoma
Central carbon metabolism in cancerhsa04014:Ras signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Oocyte meiosis
AMPK signaling pathway
Signaling pathways regulating pluripotency of stem cells
Long-term depression
Ovarian steroidogenesis
Progesterone-mediated oocyte maturation
Glioma
Prostate cancer
PANTHER Pathway Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Insulin/IGF pathway-protein kinase B signaling cascade
Pathway Interaction Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Arf6 signaling events
Signaling events mediated by TCPTP
Posttranslational regulation of adherens junction stability and dissassembly
Direct p53 effectors
Syndecan-1-mediated signaling events
Stabilization and expansion of the E-cadherin adherens junction
a6b1 and a6b4 Integrin signaling
FGF signaling pathway
Regulation of retinoblastoma proteiner_nongenomic_pathway:Plasma membrane estrogen receptor signaling
SHP2 signaling
IGF1 pathway
Integrins in angiogenesis
Reactome Sema4D mediated inhibition of cell attachment and migrationR-HSA-2428928:IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1R
WikiPathways TGF beta Signaling Pathway
Signaling of Hepatocyte Growth Factor Receptor
Focal Adhesion
Extracellular vesicle-mediated signaling in recipient cells
Signaling Pathways in Glioblastoma
miR-targeted genes in squamous cell - TarBase
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
Semaphorin interactionsWP615:Senescence and Autophagy in Cancer
Insulin Signaling
Endochondral Ossification
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Apoptosis
TSH signaling pathway
MicroRNAs in cardiomyocyte hypertrophy
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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