Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXLA4F
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| Drug Name |
4-chloro-3-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)benzamide
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| Synonyms |
CHEMBL374997
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C29H26ClF3N6O2
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| Canonical SMILES |
CNc1nccc(n1)c2cccnc2Oc3cc(ccc3Cl)C(=O)Nc4cc(ccc4N5CCCCC5)C(F)(F)F
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| InChI |
InChI=1S/C29H26ClF3N6O2/c1-34-28-36-13-11-22(38-28)20-6-5-12-35-27(20)41-25-16-18(7-9-21(25)30)26(40)37-23-17-19(29(31,32)33)8-10-24(23)39-14-3-2-4-15-39/h5-13,16-17H,2-4,14-15H2,1H3,(H,37,40)(H,34,36,38)
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| InChIKey |
PPELEVXKKDIBFP-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Angiopoietin 1 receptor | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling PathwayNetPath_8:Wnt Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathwayP00005:Angiogenesis | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling | |||||
| References | |||||
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