Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXM2ZX
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| Drug Name |
6-methoxy-7-(1-methylpiperidin-4-yloxy)-4-((1R,2S)-2-phenylcyclopropylamino)quinoline-3-carbonitrile
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| Synonyms |
CHEMBL245798
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| Indication | Discovery agent | Investigative | [1] | ||
| Formula |
C26H28N4O2
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| Canonical SMILES |
COc1cc2c(N[C@@H]3C[C@H]3c4ccccc4)c(cnc2cc1OC5CCN(C)CC5)C#N
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| InChI |
InChI=1S/C26H28N4O2/c1-30-10-8-19(9-11-30)32-25-14-22-21(13-24(25)31-2)26(18(15-27)16-28-22)29-23-12-20(23)17-6-4-3-5-7-17/h3-7,13-14,16,19-20,23H,8-12H2,1-2H3,(H,28,29)/t20-,23+/m0/s1
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| InChIKey |
QBOYVPOZZYKQRT-NZQKXSOJSA-N
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| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1] | ||
| Vascular endothelial growth factor receptor 1 | Target Info | [1] | |||
| KEGG Pathway | Ras signaling pathway | ||||
| Rap1 signaling pathway | |||||
| Cytokine-cytokine receptor interaction | |||||
| HIF-1 signaling pathway | |||||
| Endocytosis | |||||
| PI3K-Akt signaling pathway | |||||
| Focal adhesion | |||||
| Transcriptional misregulation in cancer | |||||
| Rheumatoid arthritis | |||||
| Pathway Interaction Database | Glypican 1 network | ||||
| HIF-2-alpha transcription factor network | |||||
| S1P3 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| VEGFR1 specific signals | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Reactome | Neurophilin interactions with VEGF and VEGFR | ||||
| VEGF binds to VEGFR leading to receptor dimerization | |||||
| WikiPathways | Focal Adhesion | ||||
| Signaling by VEGF | |||||
| Angiogenesis | |||||
| References | |||||
| REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 | ||||
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