Drug General Information
Drug ID
DXMA5P
Drug Name
N-tert-Butyl-2-{(3R,5R)-8-chloro-3-[3-(3-chloro-phenyl)-ureido]-2-oxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetamide
Synonyms
CHEMBL333671
Indication Discovery agent Investigative [1587926]
Formula
C29H30Cl2N4O3
Canonical SMILES
CC(C)(C)NC(=O)CN1C(=O)[C@@H](C[C@H](c2ccccc2)c3ccc(Cl)cc13)NC(=O)Nc4cccc(Cl)c4
InChI
InChI=1S/C29H30Cl2N4O3/c1-29(2,3)34-26(36)17-35-25-15-20(31)12-13-22(25)23(18-8-5-4-6-9-18)16-24(27(35)37)33-28(38)32-21-11-7-10-19(30)14-21/h4-15,23-24H,16-17H2,1-3H3,(H,34,36)(H2,32,33,38)/t23-,24-/m1/s1
InChIKey
PIYVAPZSWIDNTQ-DNQXCXABSA-N
Target and Pathway
Target(s) Gastrin/cholecystokinin type B receptor Target Info [1587926]
Cholecystokinin receptor type A Target Info [1587926]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretionhsa04020:Calcium signaling pathway
Insulin secretion
Pancreatic secretion
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-375276:Peptide ligand-binding receptors
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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