Drug General Information
Drug ID
DXN5T3
Drug Name
5-(3,3-Difluoro-allyl)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Synonyms
CHEMBL50118
Indication Discovery agent Investigative [1587926]
Formula
C23H23F2NO2
Canonical SMILES
COc1cccc2OC(CC=C(F)F)c3c(ccc4NC(C)(C)C=C(C)c34)c12
InChI
InChI=1S/C23H23F2NO2/c1-13-12-23(2,3)26-15-9-8-14-21-16(27-4)6-5-7-17(21)28-18(10-11-19(24)25)22(14)20(13)15/h5-9,11-12,18,26H,10H2,1-4H3
InChIKey
MACROYAVMFWALR-UHFFFAOYSA-N
Target and Pathway
Target(s) Progesterone receptor Target Info [1587926]
mRNA of androgen receptor Target Info [1587926]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturationhsa04114:Oocyte meiosis
Pathways in cancer
Prostate cancer
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Cellular roles of Anthrax toxinsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY network
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathway
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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