Drug General Information
Drug ID
DXPP7R
Drug Name
N-tert-Butyl-2-[(3R,5R)-2-oxo-5-phenyl-3-(3-o-tolyl-ureido)-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-acetamide
Synonyms
CHEMBL127687
Indication Discovery agent Investigative [1587926]
Formula
C30H34N4O3
Canonical SMILES
Cc1ccccc1NC(=O)N[C@@H]2C[C@H](c3ccccc3)c4ccccc4N(CC(=O)NC(C)(C)C)C2=O
InChI
InChI=1S/C30H34N4O3/c1-20-12-8-10-16-24(20)31-29(37)32-25-18-23(21-13-6-5-7-14-21)22-15-9-11-17-26(22)34(28(25)36)19-27(35)33-30(2,3)4/h5-17,23,25H,18-19H2,1-4H3,(H,33,35)(H2,31,32,37)/t23-,25-/m1/s1
InChIKey
ZMTRGKKPVWRAII-ILBGXUMGSA-N
Target and Pathway
Target(s) Gastrin/cholecystokinin type B receptor Target Info [1587926]
Cholecystokinin receptor type A Target Info [1587926]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretionhsa04020:Calcium signaling pathway
Insulin secretion
Pancreatic secretion
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-375276:Peptide ligand-binding receptors
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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