Drug Information

Drug General Information
Drug ID
DXQ9NR
Drug Name
(S)-N-hydroxy-2,2-dimethyl-4-(4-(pent-4-ynyloxy)phenylsulfonyl)thiomorpholine-3-carboxamide
Synonyms
CHEMBL441177
Indication Discovery agent Investigative [1587926]
Formula
C18H24N2O5S2
Canonical SMILES
CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c2ccc(OCCCC#C)cc2
InChI
InChI=1S/C18H24N2O5S2/c1-4-5-6-12-25-14-7-9-15(10-8-14)27(23,24)20-11-13-26-18(2,3)16(20)17(21)19-22/h1,7-10,16,22H,5-6,11-13H2,2-3H3,(H,19,21)/t16-/m0/s1
InChIKey
LWZOHIDILGLXGF-INIZCTEOSA-N
Target and Pathway
Target(s) Collagenase 3 Target Info [1587926]
Interstitial collagenase Target Info [1587926]
KEGG Pathway PPAR signaling pathway
Pathways in cancer
Bladder cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling PathwayNetPath_13:IL1 Signaling Pathway
EGFR1 Signaling Pathway
TWEAK Signaling Pathway
Wnt Signaling Pathway
PANTHER Pathway Alzheimer disease-presenilin pathway
Plasminogen activating cascadeP00004:Alzheimer disease-presenilin pathway
Plasminogen activating cascade
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalingendothelinpathway:Endothelins
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Glucocorticoid receptor regulatory network
AP-1 transcription factor network
Syndecan-1-mediated signaling events
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structuresR-HSA-1442490:Collagen degradation
Basigin interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WikiPathways Endochondral Ossification
Activation of Matrix Metalloproteinases
Oncostatin M Signaling Pathway
AGE/RAGE pathway
Matrix MetalloproteinasesWP366:TGF beta Signaling Pathway
Bladder Cancer
Degradation of collagen
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Cell surface interactions at the vascular wall
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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