Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXT3KD
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| Drug Name |
4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-phenethyloxy-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide
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| Synonyms |
CHEMBL178199
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C32H32ClN5O3
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| Canonical SMILES |
CCOc1cc2ncc(C#N)c(Nc3ccc(OCCc4ccccc4)c(Cl)c3)c2cc1NC(=O)\\C=C\\CN(C)C
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| InChI |
InChI=1S/C32H32ClN5O3/c1-4-40-30-19-27-25(18-28(30)37-31(39)11-8-15-38(2)3)32(23(20-34)21-35-27)36-24-12-13-29(26(33)17-24)41-16-14-22-9-6-5-7-10-22/h5-13,17-19,21H,4,14-16H2,1-3H3,(H,35,36)(H,37,39)/b11-8+
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| InChIKey |
GLSOBAXGEXVXAA-DHZHZOJOSA-N
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| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
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