Drug Information

Drug General Information
Drug ID
DXV07D
Drug Name
1-Methyl-1H-indole-2-carboxylic acid [5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide
Synonyms
CHEMBL73885
Indication Discovery agent Investigative [1587926]
Formula
C25H19FN4O2
Canonical SMILES
Cn1c(cc2ccccc12)C(=O)NC3N=C(c4ccccc4F)c5ccccc5NC3=O
InChI
InChI=1S/C25H19FN4O2/c1-30-20-13-7-2-8-15(20)14-21(30)24(31)29-23-25(32)27-19-12-6-4-10-17(19)22(28-23)16-9-3-5-11-18(16)26/h2-14,23H,1H3,(H,27,32)(H,29,31)
InChIKey
LLTGDDJBCQWKCP-UHFFFAOYSA-N
Target and Pathway
Target(s) Gastrin/cholecystokinin type B receptor Target Info [1587926]
Cholecystokinin receptor type A Target Info [1587926]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretionhsa04020:Calcium signaling pathway
Insulin secretion
Pancreatic secretion
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-375276:Peptide ligand-binding receptors
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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