Drug General Information
Drug ID
DXV9NK
Drug Name
(1S,2R,3R)-1-[5-(4-Methoxypyrazol-1-yl)thiophene-2-sulfonylamino]-2-methyl-3-phenylcyclopropanecarboxylic Acid
Synonyms
CHEMBL1766899
Indication Discovery agent Investigative [1]
Formula
C19H19N3O5S2
Canonical SMILES
COc1cnn(c1)c2ccc(s2)S(=O)(=O)N[C@]3([C@H](C)[C@@H]3c4ccccc4)C(=O)O
InChI
InChI=1S/C19H19N3O5S2/c1-12-17(13-6-4-3-5-7-13)19(12,18(23)24)21-29(25,26)16-9-8-15(28-16)22-11-14(27-2)10-20-22/h3-12,17,21H,1-2H3,(H,23,24)/t12-,17-,19+/m1/s1
InChIKey
DSLRBIQFKOUGKT-LLSQANQASA-N
Target and Pathway
Target(s) Interstitial collagenase Target Info [1]
Matrix metalloproteinase-14 Target Info [1]
KEGG Pathway PPAR signaling pathway
Pathways in cancer
Bladder cancer
Rheumatoid arthritishsa04668:TNF signaling pathway
GnRH signaling pathway
NetPath Pathway IL1 Signaling Pathway
EGFR1 Signaling Pathway
TWEAK Signaling Pathway
Wnt Signaling Pathway
PANTHER Pathway Alzheimer disease-presenilin pathway
Plasminogen activating cascadeP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Endothelins
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Glucocorticoid receptor regulatory network
AP-1 transcription factor network
Syndecan-1-mediated signaling eventshif2pathway:HIF-2-alpha transcription factor network
Signaling events mediated by focal adhesion kinase
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Basigin interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)R-HSA-1442490:Collagen degradation
WikiPathways TGF beta Signaling Pathway
Bladder Cancer
Activation of Matrix Metalloproteinases
Degradation of collagen
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Oncostatin M Signaling Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Cell surface interactions at the vascular wall
Matrix MetalloproteinasesWP615:Senescence and Autophagy in Cancer
AGE/RAGE pathway
Matrix Metalloproteinases
References
REF 1URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.