Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXW7BX
|
||||
| Drug Name |
4-(4,4-Dihydroxy-piperidin-1-yl)-but-2-enoic acid [4-(4-benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide
|
||||
| Synonyms |
CHEMBL362824
|
||||
| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C34H34ClN5O5
|
||||
| Canonical SMILES |
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccc4)c(Cl)c3)c2cc1NC(=O)\\C=C\\CN5CCC(O)(O)CC5
|
||||
| InChI |
InChI=1S/C34H34ClN5O5/c1-2-44-31-19-28-26(18-29(31)39-32(41)9-6-14-40-15-12-34(42,43)13-16-40)33(24(20-36)21-37-28)38-25-10-11-30(27(35)17-25)45-22-23-7-4-3-5-8-23/h3-11,17-19,21,42-43H,2,12-16,22H2,1H3,(H,37,38)(H,39,41)/b9-6+
|
||||
| InChIKey |
CBNJCHVHBCJGBE-RMKNXTFCSA-N
|
||||
| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.