Drug Information

Drug General Information
Drug ID
DXW7WN
Drug Name
4-(naphthalen-1-yldiazenyl)-1H-pyrazole-3,5-diamine
Synonyms
CHEMBL425089
Indication Discovery agent Investigative [1587926]
Formula
C13H12N6
Canonical SMILES
Nc1n[nH]c(N)c1N=Nc2cccc3ccccc23
InChI
InChI=1S/C13H12N6/c14-12-11(13(15)19-18-12)17-16-10-7-3-5-8-4-1-2-6-9(8)10/h1-7H,(H5,14,15,18,19)/b17-16+
InChIKey
ULGBLRQVUYBYQK-WUKNDPDISA-N
Target and Pathway
Target(s) Cell division protein kinase 2 Target Info [1587926]
G1/S-specific cyclin E1 Target Info [1587926]
KEGG Pathway FoxO signaling pathway
Cell cycle
Oocyte meiosis
p53 signaling pathway
PI3K-Akt signaling pathway
Progesterone-mediated oocyte maturation
Hepatitis B
Measles
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Prostate cancer
Small cell lung cancerhsa04110:Cell cycle
MicroRNAs in cancer
Small cell lung cancer
NetPath Pathway TCR Signaling PathwayNetPath_14:IL2 Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway p53 pathway
p53 pathway feedback loops 2P00013:Cell cycle
Parkinson disease
p53 pathway feedback loops 2
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by PRL
p73 transcription factor network
E2F transcription factor network
ATR signaling pathway
mTOR signaling pathway
IL2-mediated signaling events
FoxO family signaling
FOXM1 transcription factor network
BARD1 signaling events
p53 pathway
Regulation of retinoblastoma proteinprlsignalingeventspathway:Signaling events mediated by PRL
PLK3 signaling events
Regulation of retinoblastoma protein
Reactome G0 and Early G1
Activation of ATR in response to replication stress
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Processing of DNA double-strand break ends
G2 Phase
Orc1 removal from chromatin
Cyclin E associated events during G1/S transition
Cyclin A/B1 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Meiotic recombination
Factors involved in megakaryocyte development and platelet productionR-HSA-113510:E2F mediated regulation of DNA replication
G1/S-Specific Transcription
WikiPathways DNA Damage Response
ID signaling pathway
DNA Replication
G1 to S cell cycle control
M/G1 Transition
S Phase
Meiotic Recombination
Aryl Hydrocarbon Receptor
ATM Signaling Pathway
Retinoblastoma (RB) in Cancer
Spinal Cord Injury
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Prostate Cancer
Signaling Pathways in Glioblastoma
TSH signaling pathway
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Synthesis of DNA
Regulation of DNA replication
Mitotic G2-G2/M phases
Mitotic G1-G1/S phases
Factors involved in megakaryocyte development and platelet production
Cell Cycle
APC/C-mediated degradation of cell cycle proteins
Cell Cycle Checkpoints
miRNA Regulation of DNA Damage ResponseWP707:DNA Damage Response
Parkinsons Disease Pathway
Parkin-Ubiquitin Proteasomal System pathway
miRNAs involved in DNA damage response
miRNA Regulation of DNA Damage Response
Androgen receptor signaling pathway
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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