Drug Information

Drug General Information
Drug ID
DXW9X3
Drug Name
[3-(2-Chloro-benzoylamino)-5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester
Synonyms
CHEMBL72546
Indication Discovery agent Investigative [1587926]
Formula
C26H21ClFN3O4
Canonical SMILES
CCOC(=O)CN1C(=O)C(NC(=O)c2ccccc2Cl)N=C(c3ccccc3F)c4ccccc14
InChI
InChI=1S/C26H21ClFN3O4/c1-2-35-22(32)15-31-21-14-8-5-11-18(21)23(17-10-4-7-13-20(17)28)29-24(26(31)34)30-25(33)16-9-3-6-12-19(16)27/h3-14,24H,2,15H2,1H3,(H,30,33)
InChIKey
ZECBJKKPSULHJR-UHFFFAOYSA-N
Target and Pathway
Target(s) Gastrin/cholecystokinin type B receptor Target Info [1587926]
Cholecystokinin receptor type A Target Info [1587926]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretionhsa04020:Calcium signaling pathway
Insulin secretion
Pancreatic secretion
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-375276:Peptide ligand-binding receptors
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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