Drug Information

Drug General Information
Drug ID
DXX3NL
Drug Name
1-Methyl-1H-indole-2-carboxylic acid [5-(2-fluoro-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide
Synonyms
CHEMBL303227
Indication Discovery agent Investigative [1587926]
Formula
C26H21FN4O2
Canonical SMILES
CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c4ccccc4F)c5ccccc15
InChI
InChI=1S/C26H21FN4O2/c1-30-20-13-7-3-9-16(20)15-22(30)25(32)29-24-26(33)31(2)21-14-8-5-11-18(21)23(28-24)17-10-4-6-12-19(17)27/h3-15,24H,1-2H3,(H,29,32)
InChIKey
OIVTVLWHNZZBJN-UHFFFAOYSA-N
Target and Pathway
Target(s) Gastrin/cholecystokinin type B receptor Target Info [1587926]
Cholecystokinin receptor type A Target Info [1587926]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretionhsa04020:Calcium signaling pathway
Insulin secretion
Pancreatic secretion
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-375276:Peptide ligand-binding receptors
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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