Drug General Information |
Drug ID |
DXX7RZ
|
Drug Name |
4-(((3-chlorophenyl)(6-(dimethylamino)pyrimidin-4-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one
|
Synonyms |
CHEMBL1944890
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Formula |
C22H18ClF2N5O
|
Canonical SMILES |
CN(C)c1cc(ncn1)N(CC2=CC(=O)Nc3c(F)c(F)ccc23)c4cccc(Cl)c4
|
InChI |
InChI=1S/C22H18ClF2N5O/c1-29(2)18-10-19(27-12-26-18)30(15-5-3-4-14(23)9-15)11-13-8-20(31)28-22-16(13)6-7-17(24)21(22)25/h3-10,12H,11H2,1-2H3,(H,28,31)
|
InChIKey |
QSENFNYYTINYEE-UHFFFAOYSA-N
|
Target and Pathway |
Target(s) |
Nitric-oxide synthase, brain |
Target Info |
|
[1]
|
Nitric oxide synthase, inducible |
Target Info |
|
[1]
|
BioCyc Pathway
|
Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cycle
|
KEGG Pathway
|
Arginine and proline metabolism
|
Metabolic pathways
|
Calcium signaling pathway
|
Phagosome
|
Circadian entrainment
|
Long-term depression
|
Salivary secretion
|
Alzheimer's disease
|
Amyotrophic lateral sclerosis (ALS)hsa00220:Arginine biosynthesis
|
HIF-1 signaling pathway
|
Peroxisome
|
Salmonella infection
|
Pertussis
|
Leishmaniasis
|
Chagas disease (American trypanosomiasis)
|
Toxoplasmosis
|
Amoebiasis
|
Tuberculosis
|
Pathways in cancer
|
Small cell lung cancer
|
NetPath Pathway
|
EGFR1 Signaling PathwayNetPath_13:IL1 Signaling Pathway
|
IL2 Signaling Pathway
|
PANTHER Pathway
|
CCKR signaling map ST
|
Pathway Interaction Database
|
IL12-mediated signaling events
|
Alpha9 beta1 integrin signaling events
|
ATF-2 transcription factor network
|
IL23-mediated signaling events
|
Signaling mediated by p38-alpha and p38-beta
|
HIF-1-alpha transcription factor network
|
PathWhiz Pathway
|
Arginine and Proline Metabolism
|
Reactome
|
ROS production in response to bacteria
|
Nitric oxide stimulates guanylate cyclaseR-HSA-1222556:ROS production in response to bacteria
|
Nitric oxide stimulates guanylate cyclase
|
WikiPathways
|
Monoamine Transport
|
Myometrial Relaxation and Contraction Pathways
|
Amyotrophic lateral sclerosis (ALS)
|
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
|
Spinal Cord Injury
|
Alzheimers Disease
|
Effects of Nitric Oxide
|
Serotonin Transporter ActivityWP619:Type II interferon signaling (IFNG)
|
AGE/RAGE pathway
|
References |
REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 |