Drug Information

Drug General Information
Drug ID
DXZ1JN
Drug Name
N-(6-methyl-3-(3-((4-methylpiperazin-1-yl)methyl)styryl)-1H-indazol-5-yl)-2-(thiophen-2-yl)acetamide
Synonyms
CHEMBL1091231
Indication Discovery agent Investigative [1587926]
Formula
C28H31N5OS
Canonical SMILES
CN1CCN(Cc2cccc(\\C=C\\c3n[nH]c4cc(C)c(NC(=O)Cc5cccs5)cc34)c2)CC1
InChI
InChI=1S/C28H31N5OS/c1-20-15-27-24(18-26(20)29-28(34)17-23-7-4-14-35-23)25(30-31-27)9-8-21-5-3-6-22(16-21)19-33-12-10-32(2)11-13-33/h3-9,14-16,18H,10-13,17,19H2,1-2H3,(H,29,34)(H,30,31)/b9-8+
InChIKey
JNCRJZQZLMYLLM-CMDGGOBGSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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