Drug Information
Drug General Information | |||||
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Drug ID |
DXZ5EL
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Drug Name |
4-[3-Chloro-4-(3-fluorobenzyloxy)anilino]-6-[3-(2,4,5-trifluorophenylacetamido)phenoxy]pyrimidine
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Synonyms |
CHEMBL1928956
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Indication | Discovery agent | Investigative | [1587926] | ||
Formula |
C31H21ClF4N4O3
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Canonical SMILES |
Fc1cccc(COc2ccc(Nc3cc(Oc4cccc(NC(=O)Cc5cc(F)c(F)cc5F)c4)ncn3)cc2Cl)c1
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InChI |
InChI=1S/C31H21ClF4N4O3/c32-24-13-22(7-8-28(24)42-16-18-3-1-4-20(33)9-18)39-29-15-31(38-17-37-29)43-23-6-2-5-21(12-23)40-30(41)11-19-10-26(35)27(36)14-25(19)34/h1-10,12-15,17H,11,16H2,(H,40,41)(H,37,38,39)
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InChIKey |
ONRLVYYHPWCVNL-UHFFFAOYSA-N
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Target and Pathway | |||||
Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
KEGG Pathway | ErbB signaling pathway | ||||
Calcium signaling pathway | |||||
HIF-1 signaling pathway | |||||
Focal adhesion | |||||
Adherens junction | |||||
Pathways in cancer | |||||
Proteoglycans in cancer | |||||
MicroRNAs in cancer | |||||
Pancreatic cancer | |||||
Endometrial cancer | |||||
Prostate cancer | |||||
Bladder cancer | |||||
Non-small cell lung cancer | |||||
Central carbon metabolism in cancer | |||||
NetPath Pathway | TCR Signaling Pathway | ||||
PANTHER Pathway | Cadherin signaling pathway | ||||
EGF receptor signaling pathway | |||||
PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
WikiPathways | DNA Damage Response (only ATM dependent) | ||||
ErbB Signaling Pathway | |||||
EGF/EGFR Signaling Pathway | |||||
Focal Adhesion | |||||
Extracellular vesicle-mediated signaling in recipient cells | |||||
Bladder Cancer | |||||
Signaling by ERBB2 | |||||
Integrated Pancreatic Cancer Pathway | |||||
Signaling Pathways in Glioblastoma | |||||
Leptin signaling pathway | |||||
miR-targeted genes in muscle cell - TarBase | |||||
Semaphorin interactions | |||||
References |
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