Drug Information

Drug General Information
Drug ID
D00AJI
Former ID
DIB000249
Drug Name
PF-4480682
Indication Neuropathic pain [ICD9: 356.0, 356.8; ICD10:G64, G90.0] Discontinued in Phase 2 [548430]
Company
Pfizer Inc
Target and Pathway
Target(s) GABA A receptor delta subunit Target Info Modulator [550179]
Gamma-aminobutyric-acid receptor alpha-2 subunit Target Info Modulator [550179]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 548430Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025530)
Ref 550179WO patent application no. 2014,1515,17, Methods of improving microvascular integrity.

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