| Drug General Information |
| Drug ID |
D00ANJ
|
| Former ID |
DNC007188
|
| Drug Name |
1-dodecyl-1H-indole-2,3-dione
|
| Synonyms |
1-dodecylindoline-2,3-dione
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C20H29NO2
|
| Canonical SMILES |
CCCCCCCCCCCCN1C2=CC=CC=C2C(=O)C1=O
|
| InChI |
1S/C20H29NO2/c1-2-3-4-5-6-7-8-9-10-13-16-21-18-15-12-11-14-17(18)19(22)20(21)23/h11-12,14-15H,2-10,13,16H2,1H3
|
| InChIKey |
GQEQKTGRIPEAKW-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Liver carboxylesterase |
Target Info |
Inhibitor |
[1]
|
|---|
| M-phase inducer phosphatase 1 |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
Drug metabolism - other enzymes
|
|
Metabolic pathwayshsa04110:Cell cycle
|
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Progesterone-mediated oocyte maturation
|
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MicroRNAs in cancer
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NetPath Pathway
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IL4 Signaling Pathway
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TGF_beta_Receptor Signaling Pathway
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Pathway Interaction Database
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E2F transcription factor networke2f_pathway:E2F transcription factor network
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ATR signaling pathway
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Validated targets of C-MYC transcriptional activation
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ATM pathway
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|
Reactome
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E2F mediated regulation of DNA replication
|
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G0 and Early G1
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Polo-like kinase mediated events
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Cyclin B2 mediated events
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Activation of ATR in response to replication stress
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Cyclin E associated events during G1/S transition
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G1/S-Specific Transcription
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Cyclin A/B1 associated events during G2/M transition
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Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
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Cyclin A:Cdk2-associated events at S phase entry
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WikiPathways
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NRF2 pathway
|
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Nuclear Receptors Meta-Pathway
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Heroin metabolism
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Irinotecan Pathway
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Fluoropyrimidine Activity
|
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Phase I biotransformations, non P450WP707:DNA Damage Response
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G1 to S cell cycle control
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S Phase
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ATM Signaling Pathway
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Retinoblastoma (RB) in Cancer
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Prostate Cancer
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Integrated Breast Cancer Pathway
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Integrated Cancer pathway
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Mitotic G1-G1/S phases
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Cell Cycle
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Cell Cycle Checkpoints
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miRNAs involved in DNA damage response
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miRNA Regulation of DNA Damage Response
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| References |
| REF 1 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. |
|---|
| REF 2 | Bioorg Med Chem Lett. 2008 Jun 1;18(11):3350-3. Epub 2008 Apr 15.Design and synthesis of N-alkyl oxindolylidene acetic acids as a new class of potent Cdc25A inhibitors. |
|---|
