Drug General Information
Drug ID	D00ASH
Former ID	DNC000063
Drug Name	3-methoxydesaminokynurenine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[535837]
Structure		Download 2D MOL 3D MOL
Formula	C12H15NO4
Canonical SMILES	CC(CC(=O)C1=CC(=CC=C1)OC)(C(=O)O)N
InChI	1S/C12H15NO4/c1-12(13,11(15)16)7-10(14)8-4-3-5-9(6-8)17-2/h3-6H,7,13H2,1-2H3,(H,15,16)
InChIKey	WRBHWPHQKJOLHX-UHFFFAOYSA-N
PubChem Compound ID	56603744
PubChem Substance ID	134339603
Target and Pathway
Target(s)	Kynureninase	Target Info	Inhibitor	[535837]
BioCyc Pathway	Superpathway of tryptophan utilization
	Tryptophan degradation
	L-kynurenine degradation
	Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
	NAD de novo biosynthesis
KEGG Pathway	Tryptophan metabolism
	Metabolic pathways
NetPath Pathway	TSLP Signaling Pathway
PathWhiz Pathway	Tryptophan Metabolism
Reactome	Tryptophan catabolism
WikiPathways	Tryptophan metabolism
	Metabolism of amino acids and derivatives
	NAD Biosynthesis II (from tryptophan)
	Selenium Micronutrient Network
References
Ref 535837	Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase. BMC Biochem. 2003 Sep 24;4:13.
Ref 535837	Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase. BMC Biochem. 2003 Sep 24;4:13.

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