Drug Information

Drug General Information
Drug ID
D00BHL
Former ID
DNCL002585
Drug Name
EC20
Synonyms
Technetium Tc-99m etarfolatide
Drug Type
Small molecular drug
Indication Ovarian cancer [ICD9: 183; ICD10:C56] Phase 3 [547956]
Company
Endocyte
Structure
Download
2D MOL

3D MOL
Formula
C29H31N11O12STc-2
Canonical SMILES
C1=CC(=CC=C1C(=O)NC(CCC(=O)NCC(C(=O)[N-]C(CC(=O)O)C(=O)<br />[N-]C(C[S-])C(=O)O)[NH-])C(=O)O)NCC2=CN=C3C(=N2)C(=O)N=<br />C(N3)N.O=[Tc+2]
InChI
1S/C29H34N11O11S.O.Tc/c30-15(24(45)37-17(7-20(42)43)25(46)38-18(11-52)28(50)51)10-33-19(41)6-5-16(27(48)49)36-23(44)12-1-3-13(4-2-12)32-8-14-9-34-22-21(35-14)26(47)40-29(31)39-22;;/h1-4,9,15-18,30H,5-8,10-11H2,(H12,31,32,33,34,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52);;/q-1;;+2/p-3/t15-,16+,17-,18-;;/m0../s1/i;;1+1
InChIKey
WPJIUTNIQZYLOW-SCBMDYCNSA-K
PubChem Compound ID
44241479
PubChem Substance ID
85261498
Target and Pathway
Target(s) Folate receptor alpha Target Info Modulator [550882]
KEGG Pathway Endocytosis
Reactome COPII (Coat Protein 2) Mediated Vesicle Transport
Cargo concentration in the ER
WikiPathways Folate Metabolism
References
Ref 547956Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020691)
Ref 550882EP patent application no. 2822386, Folate receptor alpha binding ligands.

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