| Drug General Information |
| Drug ID |
D00CDF
|
| Former ID |
DIB018851
|
| Drug Name |
andarine
|
| Synonyms |
GTX007; GTX-007
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C19H18F3N3O6
|
| InChI |
InChI=1S/C19H18F3N3O6/c1-11(26)23-12-3-6-14(7-4-12)31-10-18(2,28)17(27)24-13-5-8-16(25(29)30)15(9-13)19(20,21)22/h3-9,28H,10H2,1-2H3,(H,23,26)(H,24,27)/t18-/m0/s1
|
| InChIKey |
YVXVTLGIDOACBJ-SFHVURJKSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
14783679, 16356819, 24127334, 44922700, 46518728, 50075683, 51091126, 77753267, 87325162, 87557517, 99436998, 99443894, 103354676, 109692985, 118843816, 121380285, 124757027, 125163831, 126671644, 131480700, 136340309, 136367327, 136368098, 137006451, 137275994, 142268276, 144115609, 151980501, 152258346, 152344170, 160647184, 160657742, 160968502, 162011824, 162037461, 164042433, 164827207, 170497626, 172650052, 172914177, 174529284, 177749786, 184819094, 188899523, 198981980, 223366179, 223556770, 223669590, 223704968, 228777798
|
| Target and Pathway |
| Target(s) |
mRNA of androgen receptor |
Target Info |
Agonist |
[1]
|
|---|
|
KEGG Pathway
|
Oocyte meiosis
|
|
Pathways in cancer
|
|
Prostate cancer
|
|
NetPath Pathway
|
EGFR1 Signaling Pathway
|
|
AndrogenReceptor Signaling Pathway
|
|
FSH Signaling Pathway
|
|
Pathway Interaction Database
|
Regulation of nuclear SMAD2/3 signaling
|
|
Coregulation of Androgen receptor activity
|
|
Regulation of Androgen receptor activity
|
|
Nongenotropic Androgen signaling
|
|
Regulation of nuclear beta catenin signaling and target gene transcription
|
|
FOXA1 transcription factor network
|
|
Notch-mediated HES/HEY network
|
|
Reactome
|
Nuclear Receptor transcription pathway
|
|
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
|
|
WikiPathways
|
SIDS Susceptibility Pathways
|
|
Integrated Pancreatic Cancer Pathway
|
|
Prostate Cancer
|
|
Integrated Breast Cancer Pathway
|
|
Nuclear Receptors
|
|
Androgen receptor signaling pathway
|
| References |
| REF 1 | Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit. J Med Chem. 2009 Jun 25;52(12):3597-617. |
|---|
