Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00EBH
|
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| Former ID |
DIB009413
|
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| Drug Name |
ICI-170809
|
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| Synonyms |
ZM-170809
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| Drug Type |
Small molecular drug
|
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| Indication | Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] | Discontinued in Phase 2 | [1] | ||
| Company |
Zeneca Group plc
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| Structure |
|
Download2D MOL |
|||
| Formula |
C21H24N2S
|
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| Canonical SMILES |
c1(nc2c(cc1c1ccccc1)cccc2)SCC(N(C)C)(C)C.Cl
|
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| CAS Number |
CAS 85275-49-6
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | 5-HT 2 receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Serotonergic synapse | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001766) | ||||
| REF 2 | 5-HT2 receptor blockade by ICI 170,809 does not affect the inhibitory effect of the 5-HT1A receptor ligand gepirone on neuroleptic-induced catalepsy. Braz J Med Biol Res. 1994 Oct;27(10):2437-41. | ||||
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