Drug General Information
Drug ID
D00ESG
Former ID
DNC012075
Drug Name
4-Pyridin-2-yl-piperazine-1-carboxylic acid amide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527001]
Structure
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2D MOL

3D MOL

Formula
C10H14N4O
Canonical SMILES
C1CN(CCN1C2=CC=CC=N2)C(=O)N
InChI
1S/C10H14N4O/c11-10(15)14-7-5-13(6-8-14)9-3-1-2-4-12-9/h1-4H,5-8H2,(H2,11,15)
InChIKey
XYIDWLYTWKIZQC-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Vanilloid receptor Target Info Inhibitor [527001]
Vanilloid receptor 1 Target Info Inhibitor [527001]
Transient receptor potential cation channel subfamily V member 4 Target Info Inhibitor [527001]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channelshsa04750:Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channelsR-HSA-3295583:TRP channels
References
Ref 527001Bioorg Med Chem Lett. 2004 Apr 5;14(7):1693-6.N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands.
Ref 527001Bioorg Med Chem Lett. 2004 Apr 5;14(7):1693-6.N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands.

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