Drug Information

Drug General Information
Drug ID
D00HUY
Former ID
DNC003701
Drug Name
L-708568
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534017]
Structure
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2D MOL

3D MOL
Formula
C22H24N2O3
Canonical SMILES
CC1=CC(=CC(=C1)COC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C)C
InChI
1S/C22H24N2O3/c1-14-8-15(2)10-17(9-14)13-27-22(26)21(24-16(3)25)11-18-12-23-20-7-5-4-6-19(18)20/h4-10,12,21,23H,11,13H2,1-3H3,(H,24,25)/t21-/m0/s1
InChIKey
YIHWPQQGVKFHTC-NRFANRHFSA-N
PubChem Compound ID
10473960
Target and Pathway
Target(s) Substance-P receptor Target Info Inhibitor [534017]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 534017J Med Chem. 1993 Jul 9;36(14):2044-5.N-acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists.
Ref 534017J Med Chem. 1993 Jul 9;36(14):2044-5.N-acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists.

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