Drug Information

Drug General Information
Drug ID
D00HUZ
Former ID
DIB014165
Drug Name
NDDP
Synonyms
Cis-Bis(2,2-dimethyloctanoato)[trans-1(R),2(R)-diaminocyclohexane]platinum (II)
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 2 [521458]
Structure
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2D MOL

3D MOL
Formula
C26H50N2O4Pt
Canonical SMILES
CC(C)(C)CCCCCC(=O)[O-].CC(C)(C)CCCCCC(=O)[O-].C1CCC(C(C<br />1)[NH-])[NH-].[Pt+4]
InChI
1S/2C10H20O2.C6H12N2.Pt/c2*1-10(2,3)8-6-4-5-7-9(11)12;7-5-3-1-2-4-6(5)8;/h2*4-8H2,1-3H3,(H,11,12);5-8H,1-4H2;/q;;-2;+4/p-2
InChIKey
ALPHSAWEOKVWID-UHFFFAOYSA-L
CAS Number
CAS 114488-24-3
PubChem Compound ID
56841091
PubChem Substance ID
135072668, 135175126
Target and Pathway
Target(s) Human DNA Target Info Binder [533850]
References
Ref 521458ClinicalTrials.gov (NCT00004033) Liposomal-Cisplatin Analogue (L-NDDP) in Treating Patients With Malignant Pleural Mesothelioma. U.S. National Institutes of Health.
Ref 533850Cell death and DNA fragmentation induced by liposomal platinum(II) complex, L-NDDP in A2780 and A2780/PDD cells. Anticancer Res. 1994 Mar-Apr;14(2A):421-6.

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