Drug General Information
Drug ID	D00JXV
Former ID	DIB011236
Drug Name	INCB-10820
Synonyms	PF-4178903; Dual CCR2/CCR5 antagonist (inflammation), Pfizer
Indication	Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25]		Investigative	[543887]
Company	Incyte Corp
Structure		Download 2D MOL 3D MOL
Canonical SMILES	FC(F)(c1cc(N2CCN(C(=O)[C@@]3(C(C)C)CC[C@@H](N[C@@H]4[C@<br />@H](COCC4)OC)C3)CC2)ncc1)F
Target and Pathway
Target(s)	C-C chemokine receptor type 2	Target Info	Antagonist	[543887]
KEGG Pathway	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
NetPath Pathway	TCR Signaling Pathway
	IL2 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	Leptin Signaling Pathway
	RANKL Signaling Pathway
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
Reactome	Beta defensins
	Chemokine receptors bind chemokines
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Defensins
	Spinal Cord Injury
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 543887	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 59).
Ref 543887	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 59).

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