Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00KDF
|
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| Former ID |
DIB020902
|
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| Drug Name |
SB 218078
|
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| Synonyms |
SB-218078
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C24H15N3O3
|
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| InChI |
InChI=1S/C24H15N3O3/c28-23-19-17-11-5-1-3-7-13(11)26-15-9-10-16(30-15)27-14-8-4-2-6-12(14)18(22(27)21(17)26)20(19)24(29)25-23/h1-8,15-16H,9-10H2,(H,25,28,29)
|
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| InChIKey |
OTPNDVKVEAIXTI-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
4510018, 8036337, 14878684, 26759486, 36234151, 47275532, 50112911, 53837815, 56198213, 57356243, 78780473, 85789103, 99302828, 103252903, 112225998, 128860045, 134964510, 135331088, 162023407, 163125171, 163687368, 172900162, 175607508, 178102659, 179230460, 204360508, 234651240, 241376000, 249617609, 252156610, 252216263
|
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| Target and Pathway | |||||
| Target(s) | Serine/threonine-protein kinase Chk1 | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Cell cycle | ||||
| p53 signaling pathway | |||||
| HTLV-I infection | |||||
| Viral carcinogenesis | |||||
| Pathway Interaction Database | Fanconi anemia pathway | ||||
| p73 transcription factor network | |||||
| ATR signaling pathway | |||||
| Circadian rhythm pathway | |||||
| p53 pathway | |||||
| Reactome | Activation of ATR in response to replication stress | ||||
| Processing of DNA double-strand break ends | |||||
| Presynaptic phase of homologous DNA pairing and strand exchange | |||||
| G2/M DNA damage checkpoint | |||||
| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | |||||
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | |||||
| WikiPathways | DNA Damage Response | ||||
| Signaling by SCF-KIT | |||||
| ATM Signaling Pathway | |||||
| Retinoblastoma (RB) in Cancer | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Prostate Cancer | |||||
| Integrated Breast Cancer Pathway | |||||
| Integrated Cancer pathway | |||||
| Cell Cycle | |||||
| Cell Cycle Checkpoints | |||||
| miRNA Regulation of DNA Damage Response | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6037). | ||||
| REF 2 | An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage. Cancer Res. 2000 Feb 1;60(3):566-72. | ||||
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