Drug General Information
Drug ID	D00KLR
Former ID	DNC014590
Drug Name	3-Amino-propane-1-sulfonic acid
Synonyms	3-ammoniopropane-1-sulfonate
Indication	Discovery agent		Investigative	[551302]
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C(CN)CS(=O)(=O)O
InChI	1S/C3H9NO3S/c4-2-1-3-8(5,6)7/h1-4H2,(H,5,6,7)
InChIKey	SNKZJIOFVMKAOJ-UHFFFAOYSA-N
Target and Pathway
Target(s)	Gamma-aminobutyric acid B receptor	Target Info	Inhibitor	[551250]
	Gamma-aminobutyric acid receptor	Target Info	Inhibitor	[551302]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	GABAergic synapse
	Estrogen signaling pathway
	Morphine addiction
Reactome	Activation of G protein gated Potassium channels
	G alpha (i) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
WikiPathways	GPCRs, Class C Metabotropic glutamate, pheromone
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Potassium Channels
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 551302	A study of 3-amino-N-hydroxypropanesulfonamide derivatives as potential GABAB agonists and their fragmentation to 3-aminopropanesulfinic acid, Bioorg. Med. Chem. Lett. 6(14):1709-1714 (1996).
Ref 551250	Biological activity of 3-aminopropyl (methyl) phosphinic acid, a potent and selective GABAB agonist with CNS activity, Bioorg. Med. Chem. Lett. 3(4):515-518 (1993).
Ref 551302	A study of 3-amino-N-hydroxypropanesulfonamide derivatives as potential GABAB agonists and their fragmentation to 3-aminopropanesulfinic acid, Bioorg. Med. Chem. Lett. 6(14):1709-1714 (1996).

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