Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00KQT
|
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| Former ID |
DIB011092
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| Drug Name |
FR-129169
|
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| Indication | Arteriosclerosis [ICD9: 440; ICD10:I70] | Terminated | [1] | ||
| Company |
Fujisawa Pharmaceutical Co Ltd
|
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| Structure |
|
Download2D MOL |
|||
| Canonical SMILES |
C(=O)(NC(Cc1ccccc1)c1ccccc1)Cc1c(OCCCCCCCC)cccc1
|
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| CAS Number |
CAS 143895-84-5
|
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| Target and Pathway | |||||
| Target(s) | Liver carboxylesterase | Target Info | Modulator | [2] | |
| KEGG Pathway | Drug metabolism - other enzymes | ||||
| Metabolic pathways | |||||
| Pathway Interaction Database | E2F transcription factor network | ||||
| WikiPathways | NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | |||||
| Heroin metabolism | |||||
| Irinotecan Pathway | |||||
| Fluoropyrimidine Activity | |||||
| Phase I biotransformations, non P450 | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002683) | ||||
| REF 2 | Plasma cholesterol reducing effect of FR129169, a novel acyl-CoA:cholesterol acyltransferase inhibitor, in the rat. Jpn J Pharmacol. 1996 Jan;70(1):35-41. | ||||
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