Drug General Information
Drug ID	D00KSS
Former ID	DNC004453
Drug Name	3-(4-Methoxy-benzenesulfonyl)-propane-1-thiol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[525485]
Structure		Download 2D MOL 3D MOL
Formula	C10H14O3S2
Canonical SMILES	COC1=CC=C(C=C1)S(=O)(=O)CCCS
InChI	1S/C10H14O3S2/c1-13-9-3-5-10(6-4-9)15(11,12)8-2-7-14/h3-6,14H,2,7-8H2,1H3
InChIKey	JIFLEYNNNKKNOQ-UHFFFAOYSA-N
PubChem Compound ID	18411961
Target and Pathway
Target(s)	Collagenase 3	Target Info	Inhibitor	[525485]
	Neutrophil collagenase	Target Info	Inhibitor	[525535]
NetPath Pathway	IL1 Signaling Pathway
PANTHER Pathway	Alzheimer disease-presenilin pathway
	Plasminogen activating cascadeP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
	Assembly of collagen fibrils and other multimeric structuresR-HSA-1442490:Collagen degradation
WikiPathways	Endochondral Ossification
	Activation of Matrix Metalloproteinases
	Oncostatin M Signaling Pathway
	AGE/RAGE pathway
	Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
	Matrix Metalloproteinases
References
Ref 525485	Bioorg Med Chem Lett. 1999 Apr 5;9(7):943-8.Discovery of a novel series of selective MMP inhibitors: identification of the gamma-sulfone-thiols.
Ref 525485	Bioorg Med Chem Lett. 1999 Apr 5;9(7):943-8.Discovery of a novel series of selective MMP inhibitors: identification of the gamma-sulfone-thiols.
Ref 525535	Bioorg Med Chem Lett. 1999 Jul 5;9(13):1757-60.Synthesis and identification of conformationally constrained selective MMP inhibitors.

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