Drug General Information
Drug ID	D00MXS
Former ID	DNC013597
Drug Name	WOGONIN
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529976]
Structure		Download 2D MOL 3D MOL
Formula	C16H12O5
Canonical SMILES	COC1=C(C=C(C2=C1OC(=CC2=O)C3=CC=CC=C3)O)O
InChI	1S/C16H12O5/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9/h2-8,17,19H,1H3
InChIKey	XLTFNNCXVBYBSX-UHFFFAOYSA-N
PubChem Compound ID	5281703
Target and Pathway
Target(s)	Xanthine dehydrogenase/oxidase	Target Info	Inhibitor	[551348]
	Prostaglandin G/H synthase 2	Target Info	Inhibitor	[529976]
BioCyc Pathway	Purine nucleotides degradation
	Urate biosynthesis/inosine 5'-phosphate degradation
	Guanosine nucleotides degradation
	Adenosine nucleotides degradation
	Retinoate biosynthesis IIPWY66-393:Aspirin-triggered lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	C20 prostanoid biosynthesis
	Aspirin triggered resolvin E biosynthesis
KEGG Pathway	Purine metabolism
	Caffeine metabolism
	Drug metabolism - other enzymes
	Metabolic pathways
	Peroxisomehsa00590:Arachidonic acid metabolism
	NF-kappa B signaling pathway
	VEGF signaling pathway
	TNF signaling pathway
	Retrograde endocannabinoid signaling
	Serotonergic synapse
	Ovarian steroidogenesis
	Oxytocin signaling pathway
	Regulation of lipolysis in adipocytes
	Leishmaniasis
	Pathways in cancer
	Chemical carcinogenesis
	MicroRNAs in cancer
	Small cell lung cancer
NetPath Pathway	IL1 Signaling Pathway
	TSH Signaling Pathway
	IL4 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	IL5 Signaling Pathway
PANTHER Pathway	Adenine and hypoxanthine salvage pathway
	Purine metabolismP00019:Endothelin signaling pathway
	Inflammation mediated by chemokine and cytokine signaling pathway
	Toll receptor signaling pathway
	CCKR signaling map ST
Pathway Interaction Database	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
	S1P1 pathway
	C-MYB transcription factor network
	Signaling mediated by p38-alpha and p38-beta
	Calcium signaling in the CD4+ TCR pathway
PathWhiz Pathway	Caffeine Metabolism
	Purine MetabolismPW000044:Arachidonic Acid Metabolism
Reactome	Purine catabolism
WikiPathways	Oxidative Stress
	Effects of Nitric Oxide
	Metabolism of nucleotides
	Selenium Micronutrient NetworkWP98:Prostaglandin Synthesis and Regulation
	Arachidonic acid metabolism
	Aryl Hydrocarbon Receptor
	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
	Spinal Cord Injury
	Integrated Pancreatic Cancer Pathway
	Eicosanoid Synthesis
	Selenium Micronutrient Network
References
Ref 529976	Bioorg Med Chem Lett. 2009 Mar 15;19(6):1650-3. Epub 2009 Feb 7.Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study.
Ref 529976	Bioorg Med Chem Lett. 2009 Mar 15;19(6):1650-3. Epub 2009 Feb 7.Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study.
Ref 551348	Inhibition of cow's milk xanthine oxidase by flavonoids. J Nat Prod. 1988 Mar-Apr;51(2):345-8.

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