Drug General Information
Drug ID	D00NNI
Former ID	DIB007416
Drug Name	ASP-3652
Synonyms	FK-175; Beta 3 adrenoceptor agonists (overactive bladder), Astellas
Indication	Overactive bladder disorder [ICD9: 188, 596.51; ICD10:C67, N32.81]		Phase 2	[523939]
Company	Astellas Pharma Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	O=S(=O)(NC(=O)c1c(cc(c2ccc(CCNC[C@@H](c3ccccc3)O)cc2)cc<br />1)SC(C)C)C.Cl
Target and Pathway
Target(s)	Beta-3 adrenergic receptor	Target Info	Agonist	[548857]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Salivary secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Beta3 adrenergic receptor signaling pathway
Reactome	Adrenoceptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 523939	ClinicalTrials.gov (NCT01613586) A Randomized Study Comparing Placebo and ASP3652 in the Treatment of Women With Bladder Pain Syndrome / Interstitial Cystitis (BPS/IC). U.S. National Institutes of Health.
Ref 548857	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029610)

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