Drug General Information
Drug ID
Former ID
Drug Name
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 2 [522178]
Target and Pathway
Target(s) Alpha platelet-derived growth factor receptor Target Info Inhibitor [550402]
Mast/stem cell growth factor receptor Target Info Inhibitor [550402]
VEGF receptor Target Info Inhibitor [550402]
Beta platelet-derived growth factor receptor Target Info Inhibitor [550402]
KEGG Pathway MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Focal adhesion
Gap junction
Regulation of actin cytoskeleton
HTLV-I infection
Pathways in cancer
MicroRNAs in cancer
Prostate cancer
Central carbon metabolism in cancer
Choline metabolism in cancerhsa04014:Ras signaling pathway
Hematopoietic cell lineage
Acute myeloid leukemia
Central carbon metabolism in cancerhsa04014:Ras signaling pathway
HIF-1 signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritishsa04010:MAPK signaling pathway
Choline metabolism in cancer
NetPath Pathway TGF_beta_Receptor Signaling PathwayNetPath_15:IL3 Signaling Pathway
IL4 Signaling Pathway
KitReceptor Signaling Pathway
PANTHER Pathway Angiogenesis
PDGF signaling pathwayP00005:Angiogenesis
PDGF signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PDGFR-alpha signaling pathway
PDGF receptor signaling networkcmyb_pathway:C-MYB transcription factor network
Signaling events mediated by Stem cell factor receptor (c-Kit)ptp1bpathway:Signaling events mediated by PTP1B
Beta3 integrin cell surface interactions
S1P3 pathway
Nectin adhesion pathway
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
PDGFR-beta signaling pathway
Validated targets of C-MYC transcriptional repression
PDGF receptor signaling network
Reactome PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascadeR-HSA-1257604:PIP3 activates AKT signaling
Regulation of KIT signaling
RAF/MAP kinase cascade
WikiPathways Regulation of Actin Cytoskeleton
Osteoblast Signaling
Focal Adhesion
Hair Follicle Development: Organogenesis (Part 2 of 3)
PIP3 activates AKT signaling
Cardiac Progenitor Differentiation
Integrated Pancreatic Cancer Pathway
Allograft Rejection
Signaling Pathways in Glioblastoma
Signaling by PDGF
AngiogenesisWP304:Kit receptor signaling pathway
Differentiation Pathway
Signaling by SCF-KIT
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBaseWP51:Regulation of Actin Cytoskeleton
MAPK Signaling Pathway
PDGF Pathway
Ref 522178ClinicalTrials.gov (NCT00570635) A Phase 2 Study of XL820 in Adults With Advanced GIST Resistant to Imatinib and/or Sunitinib. U.S. National Institutes of Health.
Ref 550402National Cancer Institute Drug Dictionary (drug id 452042).

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