Drug Information

Drug General Information
Drug ID
D00NSM
Former ID
DIB010546
Drug Name
CM-GLP-1
Synonyms
CellBead Neuro; CM-GLP-1; GLP-1-expressing stem cell therapy (drug eluting bead, neurological trauma/neurodegeneration); CM-1-expressing stem cell therapy (drug eluting bead, neurological trauma/neurodegeneration), CellMed; GLP-1-expressing stem cell therapy (drug eluting bead, neurological trauma/neurodegeneration), CellMed
Indication Brain injury [ICD10:S09.90] Discontinued in Phase 1/2 [548232]
Company
CellMed AG
Target and Pathway
Target(s) Glucagon-like peptide 1 receptor Target Info Modulator [529902]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Insulin secretion
Reactome Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
G alpha (s) signalling events
Glucagon-type ligand receptors
WikiPathways GPCRs, Class B Secretin-like
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 548232Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023519)
Ref 529902Reversal of diabetes in rats using GLP-1-expressing adult pancreatic duct-like precursor cells transformed from acinar to ductal cells. Stem Cells Dev. 2009 Sep;18(7):991-1002.

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