Drug Information

Drug General Information
Drug ID
D00QCL
Former ID
DNC012026
Drug Name
SOPHOFLAVESCENOL
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526395]
Structure
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2D MOL

3D MOL
Formula
C21H20O6
Canonical SMILES
CC(=CCC1=C(C=C(C2=C1OC(=C(C2=O)O)C3=CC=C(C=C3)O)OC)O)C
InChI
1S/C21H20O6/c1-11(2)4-9-14-15(23)10-16(26-3)17-18(24)19(25)20(27-21(14)17)12-5-7-13(22)8-6-12/h4-8,10,22-23,25H,9H2,1-3H3
InChIKey
VMLJAWUWVVHRNG-UHFFFAOYSA-N
PubChem Compound ID
9929189
Target and Pathway
Target(s) CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [526395]
CGMP-specific 3',5'-cyclic phosphodiesterase Target Info Inhibitor [526395]
CGMP-inhibited 3',5'-cyclic phosphodiesterase A Target Info Inhibitor [526395]
CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [526395]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
cGMP-PKG signaling pathwayhsa00230:Purine metabolism
cGMP-PKG signaling pathway
Morphine addiction
NetPath Pathway TGF_beta_Receptor Signaling PathwayNetPath_17:IL5 Signaling Pathway
IL2 Signaling Pathway
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-418457:cGMP effectsR-HSA-418457:cGMP effects
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling PathwaysWP2005:miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBaseWP35:G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Nuclear Receptors Meta-Pathway
Opioid Signalling
References
Ref 526395Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6.A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5.
Ref 526395Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6.A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5.

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