Drug General Information
Drug ID
D00QTX
Former ID
DIB021258
Drug Name
ZK110841
Synonyms
ZK 110841; ZK-110841
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539188]
Structure
Download
2D MOL
Formula
C21H33ClO4
InChI
InChI=1S/C21H33ClO4/c22-18-14-20(24)17(12-13-19(23)15-8-4-3-5-9-15)16(18)10-6-1-2-7-11-21(25)26/h1,6,12-13,15-20,23-24H,2-5,7-11,14H2,(H,25,26)/b6-1-,13-12+/t16?,17-,18-,19-,20-/m1/s1
InChIKey
ZOQXTNLUBHPZOZ-GZFHOOQWSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Prostaglandin D2 receptor Target Info Agonist [534620]
Prostaglandin E2 receptor, EP1 subtype Target Info Agonist [526324]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
Pathways in cancer
PANTHER Pathway PI3 kinase pathway
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
Reactome Prostanoid ligand receptors
G alpha (s) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (q) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
References
Ref 539188(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1889).
Ref 526324Cloned human EP1 prostanoid receptor pharmacology characterized using radioligand binding techniques. J Pharm Pharmacol. 2002 Apr;54(4):539-47.
Ref 534620Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. Br J Pharmacol. 1998 Apr;123(7):1317-24.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.