Drug Information

Drug General Information
Drug ID
D00REB
Former ID
DIB018920
Drug Name
AZ11657312 (salt free)
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528736]
Structure
Download
2D MOL
Formula
C26H35N3O3
InChI
InChI=1S/C26H35N3O3/c1-16-2-3-20(25(31)29-14-21-12-27-13-22(15-29)32-21)7-23(16)28-24(30)11-26-8-17-4-18(9-26)6-19(5-17)10-26/h2-3,7,17-19,21-22,27H,4-6,8-15H2,1H3,(H,28,30)
InChIKey
XYNNEMHCLNODBL-UHFFFAOYSA-N
PubChem Compound ID
11193842
PubChem Substance ID
16564724, 23381593, 42273519, 75108174, 103687780, 139514546, 223366055, 230945884, 247504484
Target and Pathway
Target(s) P2X purinoceptor 7 Target Info Antagonist [543850]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome The NLRP3 inflammasome
WikiPathways Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
References
Ref 528736The role of the purinergic P2X7 receptor in inflammation. J Inflamm (Lond). 2007 Mar 16;4:5.
Ref 543850(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 484).

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