Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00RJA
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| Former ID |
DNC001506
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| Drug Name |
VX-148
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| Drug Type |
Small molecular drug
|
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| Indication | Psoriasis [ICD9: 696; ICD10:L40] | Discontinued in Phase 2 | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C23H25N5O4
|
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| Canonical SMILES |
CCC(CC#N)OC(=O)NC(C)C1=CC(=CC=C1)NC(=O)NC2=CC(=C(C=C2)C<br />#N)OC
|
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| InChI |
1S/C23H25N5O4/c1-4-20(10-11-24)32-23(30)26-15(2)16-6-5-7-18(12-16)27-22(29)28-19-9-8-17(14-25)21(13-19)31-3/h5-9,12-13,15,20H,4,10H2,1-3H3,(H,26,30)(H2,27,28,29)/t15-,20?/m0/s1
|
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| InChIKey |
PJFQWSNOXLEDDZ-OOJLDXBWSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Inosine-5'-monophosphate dehydrogenase | Target Info | Inhibitor | [2] | |
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013965) | ||||
| REF 2 | Characterization of pharmacological efficacy of VX-148, a new, potent immunosuppressive inosine 5'-monophosphate dehydrogenase inhibitor. J Pharmacol Exp Ther. 2002 Sep;302(3):1272-7. | ||||
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