TTD | Drug: D00TLM

Drug General Information
Drug ID	D00TLM
Former ID	DNC011099
Drug Name	PRUVANSERIN
Drug Type	Small molecular drug
Indication	Sleep disorders [ICD9: 307.4, 327, 780.5; ICD10:F51, G47]		Phase 2	[521764]
Structure		Download 2D MOL 3D MOL
Formula	C22H21FN4O
Canonical SMILES	C1CN(CCN1CCC2=CC=C(C=C2)F)C(=O)C3=CC=CC4=C3NC=C4C#N
InChI	1S/C22H21FN4O/c23-18-6-4-16(5-7-18)8-9-26-10-12-27(13-11-26)22(28)20-3-1-2-19-17(14-24)15-25-21(19)20/h1-7,15,25H,8-13H2
InChIKey	AQRLDDAFYYAIJP-UHFFFAOYSA-N
CAS Number	CAS 443144-26-1
PubChem Compound ID	6433122
Target and Pathway
Target(s)	5-hydroxytryptamine 2A receptor	Target Info	Modulator	[552847]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	5HT2 type receptor mediated signaling pathway
Reactome	Serotonin receptors
Reactome	G alpha (q) signalling events
WikiPathways	Serotonin Receptor 2 and STAT3 Signaling
	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 521764	ClinicalTrials.gov (NCT00259311) Efficacy Study of LY2422347 to Treat Insomnia. U.S. National Institutes of Health.
Ref 552847	5-HT(2A) inverse-agonists for the treatment of insomnia. Curr Top Med Chem. 2008;8(11):969-76.

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Drug Information